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10/14/08

Incidence: Lung cancer will affect almost 200,000 people in the United States this year, and will cause death in 170,000 of them. Smoking increases one’s risk of contracting lung cancer, but many smokers never get it and many non-smokers do. If you have been diagnosed either with lung cancer or a lung mass, it is not important what you have done in the past, but what you do in the future.

Diagnosis: Lung cancer is most often suspected on either chest radiograph or a chest CT scan. To move from a suspicion to a diagnosis requires a small piece of the cancer, to allow a pathologist to determine if there are cancerous cells. This piece of tissue can be obtained from a bronchoscopy (a scope passed into the windpipe), a fine-needle biopsy (usually done by a radiologist using CT scans), or by a surgical biopsy. It is important to know that tumors are made up of dead cells, normal cells, and cancer cells. If the biopsy contains only dead or normal cells, a false diagnosis will result. This is why surgical biopsies are the most accurate. We have at least one patient a month with cancer who undergoes a biopsy, is told they do not have cancer, and subsequently loses precious time to treat it.

Stage: It is absolutely essential to accurately stage lung cancer before commencing treatment - Staging lung cancer is important because it helps to predict how the cancer might act, and helps to direct treatment. The appropriate treatment of lung cancer depends upon how advanced the cancer is, its stage. Early cancers are best treated with surgery, while intermediate cancers (those that involve lymph nodes in the chest) are best treated with a combination of chemotherapy and surgery, and occasionally radiotherapy. Metastatic (advanced) cancer is cancer that has spread from the lung to other sites. Patients that have single metastases to their brain or adrenal glands can undergo resection of both—all other patients with metastatic, or advanced cancer are best treated with chemotherapy alone.

Staging requires searching for distant spread and for local extent. Head scans (CT or MRI), bone scans, PET (Positron Emission Tomography) scans, and chest CT scans are used to evaluate possible spread to brain, bones, liver and adrenal glands. PET scans can evaluate distant disease or, to a lesser extent nodal disease. The most accurate way to evaluate local disease is a small surgical procedure, however this procedure must be performed by an expert in the field who is capable of biopsying all the lymph node groups in the chest. If an incomplete procedure is done, the chance of complete staging and further treatment later may be lost forever. This means that anyone with suspected lung cancer must choose providers (for even initial treatment) wisely.

Stage Tumor Nodes   Metastases  
IA  Less than 3 centimeters in size (T1) 
No nodes involved 
No metastases
IB greater than 3 cm, or involving lung lining (T2)
No nodes involved 
No metastases
IIA T1
Nearby nodes involved 
No metastases
IIB Mass involves the chest wall (T3)
No nodes involved 
No metastases, or
  T2
nearby nodes involved
No metastases
IIIA T1 or T2
Chest nodes involved 
No metastases, or
  T3 
Nearby or chest involved
No metastases
IIIB lesion grows into middle of chest or causes fluid
May/may not be involved
No metastases
  May be any size 
extensive chest nodes 
No metastases
IV Any size 
May/may not be involved
metastases
  • Treatment: The vast majority of patients who are cured of non-small cell lung cancer have surgery at some point in their treatment. Patients with early lung cancer (cancers that have not spread to lymph nodes within their chest) can usually be cured with surgery. Patients with more advanced lung cancer (involving lymph nodes in the chest) require a combination of chemotherapy, surgery, and sometimes radiation to have a significant chance of cure. Patients who have limited metastatic disease (spread to brain or adrenal gland) can occasionally benefit from surgery, but in general are best treated with chemotherapy.

  • Early lung cancer (stages I and II)
    Surgery only
  • Intermediate lung cancer (stage IIIA)
    Chemotherapy followed by surgery,? radiation 
  • Advanced lung cancer (stage IV)
    Chemotherapy only

(Some patients with stage IIIB cancer can be treated with surgery, as can selected patients with stage IV disease)

General Thoracic Surgeons: Surgeons board certified in general surgery and cardiothoracic surgery who have committed themselves to the practice of diseases of the chest, only. Most surgeons who do thoracic surgery have a primary interest in belly surgery or heart surgery, and only rarely do thoracic surgery.